Muscarinic Blocking Drugs
نویسنده
چکیده
Muscarinic blocking drugs are compounds that selectively antagonize the responses to acetylcholine (ACh) and other parasympathomimetics that are mediated by activation of muscarinic receptors. These agents are also referred to as muscarinic antagonists, antimuscarinic drugs, and anticholinergics. The belladonna alkaloids, such as atropine, are the oldest known muscarinic blocking compounds, and their medicinal use preceded the concept of neurochemical transmission.
منابع مشابه
The effect of blocking of dorsal and lateral paragigantocellularis muscarinic receptors on pain scores in rats
Previous studies have shown that paragigantocellularis nucleus (PGI) neurons contain some neurotransmitters such as GABA, neuropeptides, monoamines, substance P, enkephalin and serotonin. It has been suggested that PGI is a main cholinergic source in the rat’s brain stem. There are few evidences on the presence and importance of cholinergic receptors on PGI neurons with regard to nociception. I...
متن کاملThe effect of blocking of dorsal and lateral paragigantocellularis muscarinic receptors on pain scores in rats
Previous studies have shown that paragigantocellularis nucleus (PGI) neurons contain some neurotransmitters such as GABA, neuropeptides, monoamines, substance P, enkephalin and serotonin. It has been suggested that PGI is a main cholinergic source in the rat’s brain stem. There are few evidences on the presence and importance of cholinergic receptors on PGI neurons with regard to nociception. I...
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The pharmacodynamics and pharmacokinetics of the currently available neuromuscular blocking and reversal drugs may be altered by organ disease. Adverse effects such as prolonged neuromuscular block, postoperative residual curarisation, recurarisation, the muscarinic effects of the anticholinesterases, and the side-effects of the antimuscarinics are encountered more frequently. This review will ...
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